SML0374

U-104

≥98% (HPLC)

• Synonym(e): 4-[[[(4-Fluorophenyl)amino]carbonyl]amino]-benzenesulfonamide, NSC 213841
• Empirische Formel (Hill-System): C₁₃H₁₂FN₃O₃S
• CAS-Nummer: 178606-66-1
• Molekulargewicht: 309.32
• MDL-Nummer: MFCD00159265
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825375
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: >15 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: O=C(NC1=CC=C(S(N)(=O)=O)C=C1)NC2=CC=C(F)C=C2
• InChI: 1S/C13H12FN3O3S/c14-9-1-3-10(4-2-9)16-13(18)17-11-5-7-12(8-6-11)21(15,19)20/h1-8H,(H2,15,19,20)(H2,16,17,18)
• InChIKey: YJQZNWPYLCNRLP-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

U-104 is an inhibitor of CA IX that binds only to CA IX under hypoxic conditions in vivo. The binding results in significant inhibition of tumor growth and metastasis formation in both spontaneous and experimental models of metastasis. U-104 reduces the medium acidity by inhibiting the catalytic activity of the CA IX. It binds specifically only to hypoxic cells expressing CA IX.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable