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Key Documents

SAB4500395

Sigma-Aldrich

Anti-Collagen XII α1 antibody produced in rabbit

affinity isolated antibody

Synonym(e):

COCA1, Collagen α-1(XII) chain

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 333 kDa

Speziesreaktivität

human

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

NCBI-Hinterlegungsnummer

Q99715

UniProt-Hinterlegungsnummer

Q99715

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... COL12A1(1303)

Allgemeine Beschreibung

Anti-Collagen XII α1 Antibody detects endogenous levels of total Collagen XII α1 protein.
Collagen XII α1 belongs to the FACIT collagens (fibril-associated collagens with interrupted triple helices) family. It codes for the alpha chain of type XII collagen. It is located on human chromosome 6q13.

Immunogen

The antiserum was produced against synthesized peptide derived from human Collagen XII alpha1.

Immunogen Range: 1481-1530

Anwendung

Anti-Collagen XII α1 antibody has been used in immunohistochemistry.

Biochem./physiol. Wirkung

Collagen XII α1 participates in a benign bone tumor, subungual exostosis. Collagen XII organize the collagen fibrils and thereby preserves the bone and muscle integrity. Mutations in collagen XII results in Ehlers–Danlos/myopathy overlap syndrome.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Mutations in the collagen XII gene define a new form of extracellular matrix-related myopathy.
Hicks D, et al.
Human Molecular Genetics, 23(9), 2353-2363 (2013)
Collagen XII: protecting bone and muscle integrity by organizing collagen fibrils.
Chiquet M, et al.
The International Journal of Biochemistry & Cell Biology, 53, 51-54 (2014)
Ivana Zvackova et al.
Frontiers in physiology, 8, 554-554 (2017-08-22)
Development of mammalian teeth and surrounding tissues includes time-space changes in the extracellular matrix composition and organization. This requires complex control mechanisms to regulate its synthesis and remodeling. Fibril-associated collagens with interrupted triple helices (FACITs) and a group of small
Taketoshi Yasuda et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 22(11), 1499-1506 (2009-08-04)
Chondromyxoid fibroma, a rare benign bone tumor, may be mistaken for chondrosarcoma. Although cytogenetic studies of chondromyxoid fibroma are few, rearrangements of the long arm of chromosome 6, frequently expressed as an inv(6)(p25q13), are prominent. In this study, conventional cytogenetic

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