SAB4200403

Anti-EXOSC8 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonym(e): Anit-CIP3, Anit-Exosome component 8,p9, Anti-EAP2, Anti-OIP2, Anti-Opa interacting protein 2, Anti-RP11-421P11.3, Anti-RRP43, Anti-Ribosomal RNA-processing protein 43, Anti-Rrp43p, AntiCBP-interacting protein 3
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~34 kDa
• Speziesreaktivität: mouse, human, rat
• Konzentration: ~1.0 mg/mL
• Methode(n): immunoprecipitation (IP): 1-2 μg using human HEK-293T cell lysate; western blot: 1-2 μg/mL using whole extracts of mouse A20 and rat PC12 cells
• UniProt-Hinterlegungsnummer: Q96B26
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: bovine ... EXOSC8(532080) ; dog ... EXOSC8(477300) ; human ... EXOSC8(11340) ; mouse ... Exosc8(69639)

Beschreibung

Allgemeine Beschreibung

Exosome component 8 (EXOSC8) or RRP43, a 3′ to 5′ exoribonuclease, is a component of the eukaryotic exosome (a 400 kDa complex). EXOSC8 is part of the hexameric ring, along with EXOSC4-7 and EXOSC9. This is further capped by three RNA binding subunits (EXOSC1-EXOSC3). EXOSC8 gene is mapped to human chromosome 13q13.3 and is localized in nucleus and cytoplasm.

Spezifität

Anti-EXOSC8 (N-terminal) recognizes human, mouse and rat EXOSC8.

Immunogen

peptide corresponding to the N-terminal region of human EXOSC8, conjugated to KLH.

Anwendung

Anti-EXOSC8 (N-terminal) antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.

Biochem./physiol. Wirkung

Exosome component 8 (EXOSC8) interacts with AU-rich element (ARE)-containing mRNAs and its deficiency halts growth in yeast. Mutations in the EXOSC8 gene is implicated in Ponto-cerebellar hypoplasia.

Physikalische Form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Lagerung und Haltbarkeit

For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Haftungsausschluss

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable