5.06236

Tiagabine Hydrochloride

• Synonym(e): Tiagabine Hydrochloride, GABA reuptake inhibitor, Tiagabine, Gabitril, GAT-1 GABA Transporter Inhibitor, Tiagabine
• Empirische Formel (Hill-System): C₂₀H₂₅NO₂S₂ · xHCl
• CAS-Nummer: 145821-59-6
• Molekulargewicht: 375.55 (free base basis)
• MDL-Nummer: MFCD07369025
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Qualitätsniveau: 100
• Form: solid
• Wirksamkeit: 67 nM IC₅₀
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: off-white
• Löslichkeit: water: soluble
• Lagertemp.: 2-8°C
• InChI: 1S/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/m1./s1
• InChIKey: YUKARLAABCGMCN-PKLMIRHRSA-N

Beschreibung

Allgemeine Beschreibung

A potent uptake inhibitor highly selective for GABA Transport-1 (IC₅₀ = 67 nM in vivo). Clinically used as an anticonvulsant. Often used in studies related to anxiety disorders and neural damages resulted from epileptics.

Biochem./physiol. Wirkung

Primary Target
GAT-1

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Laughlin, T., et al. 2002. J. Pharmacol. Exp. Ther.302, 1168.

Hu, Q., et al. 1997. Brain Res.753,260.
Suzdak, P., et al., 1995. Epilepsia.36, 612.
Andersen, E., et al., 1993. J. Med. Chem.36, 1716.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable