S0827

Streptokinase C from Streptococcus sp.

buffered aqueous solution, ≥50,000 units/mg protein

• EC-Nummer: 3.4.99.0 (BRENDA, IUBMB)
• UNSPSC-Code: 12352204
• NACRES: NA.54

Eigenschaften

• Rekombinant: expressed in E. coli
• Qualitätsniveau: 200
• Form: buffered aqueous solution
• Spezifische Aktivität: ≥50,000 units/mg protein
• Lagertemp.: −20°C

Beschreibung

Anwendung

Streptokinase (SK) is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare. The product has been used to measure SK activity in brain heart infusion culture supernatant fluids of the various wild-type and mutant strains of Streptococcus dysgalactiae subsp. Equisimilis.

Biochem./physiol. Wirkung

Streptokinase C is an extracellular enzyme that is produced by various strains of β-hemolytic streptococci. It is a single-chain polypeptide that exerts its fibrinolytic action indirectly by activating the circulatory plasminogen.

Einheitendefinition

One unit will liquify a standard clot of fibrinogen, plasminogen, and thrombin at pH 7.5 at 37 °C in 10 min.

Physikalische Form

Supplied as a frozen solution containing 60 mM phosphate buffer and 0.6 M glutamate. Albumin-free

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable