S0577

Streptokinase C from Streptococcus sp.

lyophilized solid, ≥3,500 unit/mg solid

• Synonym(e): Streptokinase
• EC-Nummer: 3.4.99.0 (BRENDA, IUBMB)
• UNSPSC-Code: 12352204
• NACRES: NA.54

Eigenschaften

• Biologische Quelle: bacterial (Streptococcus sp.)
• Qualitätsniveau: 200
• Rekombinant: expressed in E. coli
• Assay: 40—60% protein (biuret)
• Form: lyophilized solid
• Spezifische Aktivität: ≥3,500 unit/mg solid
• Farbe: off-white to light yellow
• Anwendung(en): life science and biopharma
• Lagertemp.: −20°C
• Angaben zum Gen: Streptococcus pyogenes ... SKC(134997)

Beschreibung

Allgemeine Beschreibung

Research area: Cell Signaling

Streptokinase is an extracellular enzyme, a single-chain polypeptide produced by several strains of β-hemolytic Streptococci. It is composed of multiple structural domains like α-, β-, and γ-domains that are involved in various functions.

Anwendung

Streptokinase C from Streptococcus sp. has been used to quantitate the survival of Staphylococcus aureus in whole human blood.

Biochem./physiol. Wirkung

Streptokinase shows fibrinolytic activity by triggering the circulatory plasminogen either via a fibrin-dependent or fibrin-independent mechanism. Streptokinase has been studied majorly in terms of its therapeutic efficacy and treating myocardial infarction to dissolve clots.

Einheitendefinition

One unit will liquify a standard clot of fibrinogen, plasminogen, and thrombin at pH 7.5 at 37 °C in 10 min.

Physikalische Form

Lyophilized powder containing approx. 50% bovine serum albumin (total protein by biuret) with sodium glutamate.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable