R6520

Rolipram

≥98% (HPLC), solid, cAMP-specific phosphodiesterase (PDE4) inhibitor

• Synonym(e): 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone, ZK 62711
• Empirische Formel (Hill-System): C₁₆H₂₁NO₃
• CAS-Nummer: 61413-54-5
• Molekulargewicht: 275.34
• EG-Nummer: 262-771-1
• MDL-Nummer: MFCD00270906
• UNSPSC-Code: 41106305
• PubChem Substanz-ID: 24278196
• NACRES: NA.77

Eigenschaften

• product name: Rolipram, solid, ≥98% (HPLC)
• Biologische Quelle: synthetic (organic)
• Assay: ≥98% (HPLC)
• Form: solid
• Farbe: white to off-white
• Löslichkeit: H₂O: 0.2 mg/mL; ethanol: 7 mg/mL; DMSO: 7.3 mg/mL
• SMILES String: COc1ccc(cc1OC2CCCC2)C3CNC(=O)C3
• InChI: 1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
• InChIKey: HJORMJIFDVBMOB-UHFFFAOYSA-N
• Angaben zum Gen: human ... LITAF(9516) , PDE3A(5139) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144) , PDE5A(8654) , PDE7A(5150) ; mouse ... Pde4a(18577) ; rat ... Adora1(29290) , Pde1b(29691) , Pde2a(81743) , Pde3a(50678) , Pde4a(25638) , Pde4b(24626) , Pde4c(290646) , Pde5a(171115)

Beschreibung

Allgemeine Beschreibung

Rolipram enhances tissue protection, anatomical repair and functional recovery. It is used to treat asthma, arthritis, Huntington′s disease and multiple sclerosis. Rolipram inhibits injury-induced reductions in cyclic AMP, which is associated with acute central nervous system injury. It functions as an antidepressant, stimulates neurite outgrowth and axonal regeneration in the presence of myelin inhibitors.

Anwendung

Rolipram has been used:

• to investigate its effects on testicular torsion–detorsion injury(36)
• to block the effects of phosphodiesterase-4 (PDE4)(37)
• as a component in chemically induced long-term potentiation (cLTP) induction media(38)

Biochem./physiol. Wirkung

Selective cAMP-specific phosphodiesterase (PDE4) inhibitor.

Leistungsmerkmale und Vorteile

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves