R8279
RG108
≥98% (HPLC), powder
Synonym(e):
N-Phthalyl-L-tryptophan
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Alle Fotos(1)
About This Item
Empirische Formel (Hill-System):
C19H14N2O4
CAS-Nummer:
Molekulargewicht:
334.33
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77
Qualitätsniveau
Assay
≥98% (HPLC)
Form
powder
Optische Aktivität
[α]/D -250 to -310°, c = 0.5 in methanol
Farbe
yellow
Löslichkeit
DMSO: >10 mg/mL
Lagertemp.
−20°C
SMILES String
OC(=O)[C@H](Cc1c[nH]c2ccccc12)N3C(=O)C4=CCCC=C4C3=O
InChI
1S/C19H16N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h3-8,10,16,20H,1-2,9H2,(H,24,25)/t16-/m0/s1
InChIKey
LMAZUAXDZRILNJ-INIZCTEOSA-N
Allgemeine Beschreibung
RG108, a non-nucleoside analog is also called [2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl) propanoic acid.
Anwendung
RG108 has been used:
- in reprogramming and increasing cell plasticity of primary multipotent mesenchymal stromal cells (MMSC)
- as an inhibitor of DNA methyltransferase (DNMTi) in human retinal pigment epithelial ARPE-19 cells
- as a DNA methyltransferase inhibitor in C33A2 cells to test its effect on papillomavirus late gene expression (HPV16)
Biochem./physiol. Wirkung
RG108 is a DNA methyltransferase (DMNT) inhibitor. It reactivates tumor suppressor gene expression (p16, SFRP1, secreted frizzled related protein-1, and TIMP-3) in tumor cells by DNA demethylation. RG108 also inhibits human tumor cell line (HCT116, NALM-6) proliferation and increased doubling time in culture.
RG108 is less cytotoxic compared to azacytidine (5-Aza-dCR). It mediates radiosensitivity in esophageal cancer cells (EC). RG108 is a potent epigenetic modulator and a demethylating agent. It elicits non-cytotoxic functionality and may be useful in stem cell therapies based on human bone marrow-derived mesenchymal stem cells (hBMSCs). It interacts with DNA methyltransferase 1 at the catalytic domain region.
Leistungsmerkmale und Vorteile
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Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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