PZ0345

PF-06700841 tosylate salt

≥98% (HPLC)

• Synonym(e): [(1S)-2,2-Difluorocyclopropyl][3-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]-methanone tosylate salt
• Empirische Formel (Hill-System): C₁₈H₂₁F₂N₇O · C₇H₈O₃S
• CAS-Nummer: 1883299-62-4
• Molekulargewicht: 561.60
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329823853
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 5 mg/mL, clear (warmed)
• Lagertemp.: room temp
• SMILES String: FC1(F)C[C@H]1C(N2[C@H]3CN(C4=CC=NC(NC5=CN(C)N=C5)=N4)C[C@@H]2CC3)=O.CC6=CC=C(S(=O)(O)=O)C=C6

Beschreibung

Anwendung

PF-06700841 tosylate salt has been used as an inhibitor of Janus kinase1 (JAK1) to study its therapeutic effect on the adjuvant induced arthritis (AIA) rat model. It has also been used as an inhibitor of interferon-α/β receptor alpha chain (IFNAR1) signaling adaptor tyrosine kinase (2TYK2) in mice.

Biochem./physiol. Wirkung

PF-06700841 is an inhibitor of JAK1 and TYK2 kinases. PF-06700841 has been investigated for the treatment of psoriasis and lupus.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable