PZ0316

PF-06651600

≥98% (HPLC)

• Synonym(e): 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malonate, PF 06651600
• Empirische Formel (Hill-System): C₁₅H₁₉N₅O · C₃H₄O₄
• CAS-Nummer: 1792180-81-4
• Molekulargewicht: 389.41
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329823834
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: H₂O: 5 mg/mL, clear (warmed)
• Lagertemp.: room temp
• SMILES String: C[C@@H]1N(C(C=C)=O)C[C@H](NC2=NC=NC3=C2C=CN3)CC1.OC(CC(O)=O)=O
• InChI: 1S/C15H19N5O.C3H4O4/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15;4-2(5)1-3(6)7/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19);1H2,(H,4,5)(H,6,7)/t10-,11+;/m0./s1
• InChIKey: QMPMPSGDPRHZCG-VZXYPILPSA-N

Beschreibung

Biochem./physiol. Wirkung

PF-06651600 is a potent and selective JAK3 inhibitor.

PF-06651600 specifically targets the ATP (adenosine triphosphate)-binding domain of JAK3 (Janus kinase 3). Loss of function of JAK3 is associated with severe combined immunodeficiency syndrome.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable