N2540

NS5806

≥98% (HPLC)

• Synonym(e): N-[3,5-bis(trifluoromethyl)phenyl]-N′-[2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl]-urea
• Empirische Formel (Hill-System): C₁₆H₈Br₂F₆N₆O
• CAS-Nummer: 426834-69-7
• Molekulargewicht: 574.07
• MDL-Nummer: MFCD18432708
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329818416
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to faint yellow
• Löslichkeit: DMSO: >30 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: FC(F)(F)c1cc(NC(=O)Nc2c(Br)cc(Br)cc2-c3nnn[nH]3)cc(c1)C(F)(F)F
• InChI: 1S/C16H8Br2F6N6O/c17-8-4-10(13-27-29-30-28-13)12(11(18)5-8)26-14(31)25-9-2-6(15(19,20)21)1-7(3-9)16(22,23)24/h1-5H,(H2,25,26,31)(H,27,28,29,30)
• InChIKey: UZWJWROOLOOCPQ-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

NS5806 increases peak current amplitude of the potassium channel Kv4.3 (EC50 = 5.3 uM). NS5806 also slows Kv4.3 and Kv4.2 current dacay in channel complexes containing KChIP2. In ventricular cardiomycytes, NS5806 increases transient outward current and reproduces the electrocardiographic profile of Brugada syndrome.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301,H413
• P-Sätze: P264 - P270 - P273 - P301 + P310 - P405 - P501
• Gefahreneinstufungen: Acute Tox. 3 Oral - Aquatic Chronic 4
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable