N7758

Naloxon -hydrochlorid Dihydrat

≥98% (TLC and titration), powder

• Empirische Formel (Hill-System): C₁₉H₂₁NO₄ · HCl · 2H₂O
• CAS-Nummer: 51481-60-8
• Molekulargewicht: 399.87
• Beilstein: 6260807
• MDL-Nummer: MFCD00150901
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278050
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (TLC and titration)
• Form: powder
• Optische Aktivität: [α]25/D −178.6°, c = 2.5 in H₂O(lit.)
• Farbe: white to off-white
• Löslichkeit: ethanol: 3.3 mg/mL; H₂O: 50 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: O.O.Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC=C
• InChI: 1S/C19H21NO4.ClH.2H2O/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;;;/h2-4,14,17,21,23H,1,5-10H2;1H;2*1H2/t14-,17+,18+,19-;;;/m1.../s1
• InChIKey: TXMZWEASFRBVKY-IOQDSZRYSA-N
• Angaben zum Gen: human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988) , OPRS1(10280)

Beschreibung

Anwendung

Naloxone hydrochloride dihydrate has been used in:

• isotonic saline and injected subcutaneously into experimental rats to study its involvement with withdrawal syndrome in morphine-dependent rats
• as opioid receptor antagonist to examine the role of the endogenous opioid system in infantile amnesia for contextual fear
• as a reference neutral antagonist to define the maximum effect (Emax) of the system

Biochem./physiol. Wirkung

Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.

Leistungsmerkmale und Vorteile

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Vorsicht

Light sensitive.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves