N1019

(−)-Nicotine hemisulfate salt

≥95% (TLC), ~35 % (w/v) in H₂O (based on free base)

• Synonym(e): (−)-1-Methyl-2-(3-pyridyl)pyrrolidine
• Lineare Formel: (C₁₀H₁₄N₂)₂ · H₂SO₄
• CAS-Nummer: 65-30-5
• Molekulargewicht: 422.54
• MDL-Nummer: MFCD00148918
• UNSPSC-Code: 12352210
• PubChem Substanz-ID: 24897454
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (TLC)
• Form: liquid
• Konzentration: ~35 % (w/v) in H₂O (based on free base)
• Farbe: dark brown
• SMILES String: OS(O)(=O)=O.CN1CCC[C@H]1c2cccnc2.CN3CCC[C@H]3c4cccnc4
• InChI: 1S/2C10H14N2.H2O4S/c2*1-12-7-3-5-10(12)9-4-2-6-11-8-9;1-5(2,3)4/h2*2,4,6,8,10H,3,5,7H2,1H3;(H2,1,2,3,4)/t2*10-;/m00./s1
• InChIKey: IECQULMJVNSKDB-RCWTXCDDSA-N
• Angaben zum Gen: human ... CHRNA4(1137) , CHRNB2(1141)

Beschreibung

Allgemeine Beschreibung

Nicotine is found in the leaves of Nicotiana species. It binds to nicotinic acetylcholine receptors and inhibits endogenous neurotransmitters. Nicotine is associated with lung cancer development and reduces the efficiency of chemotherapeutic agents. It is used to treat Alzheimer′s and Parkinson′s disease.

Anwendung

(−)-Nicotine hemisulfate salt has been used to study the influence of nicotine on the severity of choroidal neovascularization (CNV). It also has been used as a natural nectar alkaloid to study the effect of self-medication in bumblebees.

Biochem./physiol. Wirkung

Prototyp der Nikotinacetylcholinrezeptoragonisten; natürlich vorkommendes Isomer.

Qualität

Mixture of nicotine base and nicotine sulfate.

Vorsicht

Shelf-life of the solution as supplied is at least six years when stored at room temperature.

Sicherheitshinweise

• Piktogramme: GHS06,GHS09
• Signalwort: Danger
• H-Sätze: H301 - H310 + H330 - H411
• P-Sätze: P260 - P262 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Gefahreneinstufungen: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2
• Lagerklassenschlüssel: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3