N0267

(±)-Nikotin

≥99% (TLC), liquid

• Empirische Formel (Hill-System): C₁₀H₁₄N₂
• CAS-Nummer: 22083-74-5
• Molekulargewicht: 162.23
• Beilstein: 82108
• MDL-Nummer: MFCD00065370
• UNSPSC-Code: 12352210
• eCl@ss: 39151701
• PubChem Substanz-ID: 24897418
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥99% (TLC)
• Form: liquid
• Optische Aktivität: [α]25/D 0°(lit.)
• Farbe: yellow
• Löslichkeit: ethanol: 50 mg/mL
• Dichte: 1.02 g/mL at 25 °C (lit.)
• SMILES String: CN1CCCC1c2cccnc2
• InChI: 1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3
• InChIKey: SNICXCGAKADSCV-UHFFFAOYSA-N
• Angaben zum Gen: human ... CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) ; rat ... Chrna3(25101) , Chrna4(25590) , Chrna7(25302)

Beschreibung

Anwendung

(±)-Nicotine has been used:

• as a supplement of high-glucose Dulbecco′s modified Eagle′s medium, to test its effect on mesenchymal stem cells
• as a standard for the determination of nicotine concentration using phase high-pressure liquid chromatography
• as a test compound to study its effects on fibril formation

Biochem./physiol. Wirkung

(±)-Nicotine is a tertiary amine compound that is predominantly present in tobacco. It binds to the nicotinic cholinergic receptors of the brain, autonomic ganglia and neuromuscular junction. Nicotine allosterically regulates a number of biological events such as production of growth hormone, dopamine, adrenocorticotropic hormone and prolactin. Nicotine absorption across biological membranes is pH sensitive, which alters its ionization state. Absorption of nicotine is shown to be higher at alkaline pH, when it remains unionized. Nicotine metabolism occurs extensively in the liver and it can cross placenta.

Prototype nicotinic acetylcholine receptor agonist.

Sicherheitshinweise

• Piktogramme: GHS06,GHS05,GHS09
• Signalwort: Danger
• H-Sätze: H300 + H310 + H330,H315,H318,H411
• P-Sätze: P262 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): 213.8 °F - closed cup
• Flammpunkt (°C): 101 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter