M8816

Microsomes from Liver, Pooled

from Monkey(Cynomolgus spp.), male

• Synonym(e): lab equipment accessory
• UNSPSC-Code: 12161501
• NACRES: NB.35

Eigenschaften

• Biologische Quelle: Monkey (Cynomolgus spp.)
• Form: liquid
• Spezifische Aktivität: ≥5000 units/mg protein
• Verpackung: vial of ~10 mg
• Versandbedingung: dry ice
• Lagertemp.: −70°C

Beschreibung

Anwendung

Microsomes from Liver, Pooled has been used to measure the in vitro stabilities of the prodrugs. It has also been used in microsomal incubation to generate BTX-3 metabolites to serve as references for liquid chromatography with tandem mass spectrometry (LC-MS/MS) analyses of urine.

Biochem./physiol. Wirkung

Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.

Microsomal cytochrome P450 proteins can catalyze the transfer of a single oxygen atom to endogenous and exogenous compounds, like steroids and phenobarbital, meant for excretion and detoxification.

Einheitendefinition

One unit will produce 1.0 picomole of 6 beta-hydroxytestosterone per minute at pH 7.4 at 37 deg C.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable