M1275

Naproxen Natrium

98.0-102.0%

• Synonym(e): (S)-6-Methoxy-α-methyl-2-naphthalinessigsäure Natriumsalz
• Empirische Formel (Hill-System): C₁₄H₁₃NaO₃
• CAS-Nummer: 26159-34-2
• Molekulargewicht: 252.24
• EG-Nummer: 247-486-2
• MDL-Nummer: MFCD00058507
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 57654352
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Qualitätsniveau: 200
• Assay: 98.0-102.0%
• Form: powder
• Löslichkeit: water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow
• Ersteller: Bayer
• SMILES String: [Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O
• InChI: 1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1
• InChIKey: CDBRNDSHEYLDJV-FVGYRXGTSA-M
• Angaben zum Gen: human ... PTGS1(5742) , PTGS2(5743)

Beschreibung

Allgemeine Beschreibung

Naproxen belongs to phenylacetic acid class of Non-steroidal anti-inflammatory drugs (NSAIDs).

Anwendung

Naproxen sodium has been used to evaluate the thermodynamics of biomolecular interaction with bovine and human serum albumin. It has also been used to evaluate its efficiency in reducing the response of spinal dorsal horn neurons to noxious knee joint rotation.

Biochem./physiol. Wirkung

Naproxen binds preferably to serum albumin. The S-enantiomer of naproxen is 28-fold more potential as an anti-inflammatory drug compared to the R-isomer. The R-isomer is found to be a liver toxin and causes gastrointestinal disorders.

Cyclooxygenase (Prostaglandin H-Synthase 1 und 2)-Hemmer.

Leistungsmerkmale und Vorteile

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Danger
• H-Sätze: H302,H360
• P-Sätze: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Gefahreneinstufungen: Acute Tox. 4 Oral - Repr. 1A
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves