K1751

Ketoprofen

≥98% (TLC), powder, non-steroidal anti-inflammatory compound

• Synonym(e): 2-(3-Benzoylphenyl)-propionsäure
• Empirische Formel (Hill-System): C₁₆H₁₄O₃
• CAS-Nummer: 22071-15-4
• Molekulargewicht: 254.28
• EG-Nummer: 244-759-8
• MDL-Nummer: MFCD00055790
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 57654315
• NACRES: NA.77

Eigenschaften

• product name: Ketoprofen, ≥98% (TLC)
• Biologische Quelle: synthetic
• Assay: ≥98% (TLC)
• Form: powder
• Löslichkeit: ethanol: 50 mg/mL, clear, colorless to yellow
• Ersteller: Bayer
• SMILES String: CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2
• InChI: 1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)
• InChIKey: DKYWVDODHFEZIM-UHFFFAOYSA-N
• Angaben zum Gen: human ... ALB(213) , IL8RA(3577) , PTGS1(5742) , PTGS2(5743)

Beschreibung

Allgemeine Beschreibung

Ketoprofen belongs to the class of 2-arylpropionic acid.

Anwendung

Ketoprofen has been used:

• as sample to analyse the effects of long storage period by chromatographic and microscopic techniques
• as a nonselective COX inhibitor to inject subcutaneously in rats to study its effect on stress/methamphetamine hydrochloride-induced changes in occludin, claudin-5 and COX-2 protein immunoreactivity, truncation of β-dystroglycan, brain water content and fluorescein isothiocyanate-dextran extravasation
• in phosphate buffer to study its ability to inhibit heat-induced denaturation of albumin

Biochem./physiol. Wirkung

It serves as an efficient drug to treat ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. It also has antipyretic and analgesic effects. Ketoprofen prevents the action of prostaglandin synthetase.

Nicht-steroidaler Entzündungshemmer, selektiv für COX-1.

Leistungsmerkmale und Vorteile

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS06,GHS09
• Signalwort: Danger
• H-Sätze: H301,H315,H319,H400
• P-Sätze: P264 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges