F5053

Flavin-Containing Monooxygenase-3, Microsomes human

recombinant, expressed in baculovirus infected insect cells, buffered aqueous solution

• Synonym(e): FMO-3
• EC-Nummer: 1.14.13.8 (BRENDA, IUBMB)
• UNSPSC-Code: 12352204
• NACRES: NA.54

Eigenschaften

• Rekombinant: expressed in baculovirus infected insect cells
• Qualitätsniveau: 200
• Form: buffered aqueous solution
• Mol-Gew.: 55-60 kDa
• Verpackung: vial of 2.5 mg
• UniProt-Hinterlegungsnummer: P31513
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• Angaben zum Gen: human ... FMO3(2328)

Beschreibung

Allgemeine Beschreibung

Flavin-Containing Monooxygenase-3 (FMO3) is a member of the flavin-containing monooxygenase (FMO) family of enzymes. It is highly expressed in the human liver.

Anwendung

FMO3 is the major human hepatic form.

Biochem./physiol. Wirkung

Flavin-Containing Monooxygenase-3 (FMO3) facilitates the oxidization of several drugs, chemicals, and xenobiotics. Human FMO3 is also involved in the synthesis of N-oxide of trimethylamine (TMAO) from trimethylamine (TMA). Mutations in the FMO3 gene are associated with trimethylaminuria or fish odor syndrome. Deficiency of the FMO3 gene results in lower plasma TMAO levels, which may reduce the risk of developing atherosclerosis and thrombosis.

Physikalische Form

Solution in 100 mM potassium phosphate buffer, pH 7.4

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)