F3503

5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt

~85%

• Synonym(e): FdUMP
• Empirische Formel (Hill-System): C₉H₁₂FN₂O₈P
• CAS-Nummer: 103226-10-4
• Molekulargewicht: 326.17
• MDL-Nummer: MFCD00057409
• UNSPSC-Code: 41106305
• PubChem Substanz-ID: 24894845
• NACRES: NA.51

Eigenschaften

• Assay: ~85%
• Qualitätsniveau: 200
• Form: solid
• Lagertemp.: −20°C
• SMILES String: [Na].OC1CC(OC1COP(O)(O)=O)N2C=C(F)C(=O)NC2=O
• InChI: 1S/C9H12FN2O8P.Na.H/c10-4-2-12(9(15)11-8(4)14)7-1-5(13)6(20-7)3-19-21(16,17)18;;/h2,5-7,13H,1,3H2,(H,11,14,15)(H2,16,17,18);;
• InChIKey: DGEOOGBABXVZPJ-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

5- 5-fluoro-2′-deoxyuridylate (FdUMP) is an intracellularly generated metabolite of 5-Fluorouracil (5-FU), a widely used reagent in molecular biology to study DNA synthesis and metabolism.

Anwendung

It has been used:

• as an anti-mitotic agent for culturing mouse primary cortical neurons.
• as a component of feeding media in the culturing of mouse primary cortical neurons.
• in studies on the activity and function of thymidylate synthase (TS).

Biochem./physiol. Wirkung

5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt (FdUMP) is an DNA synthesis inhibitor. FdUMP along with RNA synthesis inhibitor 3′-C-ethinylcytidine induces cell death in cervical cancer cells at nanomolar concentrations.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Warning
• H-Sätze: H302 + H312 + H332,H351
• P-Sätze: P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges