D9696

Dronedaron -hydrochlorid

≥98% (HPLC)

• Synonym(e): N-{2-Butyl-3-[4-(3-dibutylaminopropoxy)-benzoyl]-benzofuran-5-yl}-methansulfonamid -hydrochlorid
• Empirische Formel (Hill-System): C₃₁H₄₄N₂O₅S · HCl
• CAS-Nummer: 141625-93-6
• Molekulargewicht: 593.22
• MDL-Nummer: MFCD00914940
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329798909
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to off-white
• Löslichkeit: DMSO: 15 mg/mL, clear
• Ersteller: Sanofi Aventis
• Lagertemp.: 2-8°C
• SMILES String: Cl.CCCCN(CCCC)CCCOc1ccc(cc1)C(=O)c2c(CCCC)oc3ccc(NS(C)(=O)=O)cc23
• InChI: 1S/C31H44N2O5S.ClH/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3;/h13-18,23,32H,5-12,19-22H2,1-4H3;1H
• InChIKey: DWKVCQXJYURSIQ-UHFFFAOYSA-N
• Angaben zum Gen: human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779) , HCN4(10021) , KCNJ2(3759) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

Beschreibung

Anwendung

Dronedarone hydrochloride has been used as an anti-arrhythmic drug to assess its impact in P19C5 embryoid bodies (EBs). It has also been used to determine its antiviral potency.

Biochem./physiol. Wirkung

Dronedarone is a Class III antiarrhythmic and a multi-channel blocker for atrial fibrillation. It blocks potassium, sodium, and calcium channels and also exhibits antiadrenergic properties.

Dronedarone is a synthetic derivative of amiodarone, which belongs to the class of benzofurane anti-arrhythmic compounds. It might moderately block cytochrome P450 3A4 (CYP3A4) activity. Dronedarone is used to treat atrial flutter.

Leistungsmerkmale und Vorteile

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable