D5446

7,8-Dihydroxyflavonhydrat

≥98% (HPLC)

• Empirische Formel (Hill-System): C₁₅H₁₀O₄ · xH₂O
• CAS-Nummer: 38183-03-8
• Molekulargewicht: 254.24 (anhydrous basis)
• EG-Nummer: 253-812-4
• MDL-Nummer: MFCD00006836
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329798806
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Lagerbedingungen: desiccated
• Löslichkeit: DMSO: 24 mg/mL
• Lagertemp.: room temp
• SMILES String: Oc1ccc2C(=O)C=C(Oc2c1O)c3ccccc3
• InChI: 1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
• InChIKey: COCYGNDCWFKTMF-UHFFFAOYSA-N

Beschreibung

Anwendung

7,8-Dihydroxyflavone hydrate has been used as tropomyosin-receptor-kinase B (TrkB) agonist in mice and to inhibit TrkB for monitoring evoked excitatory postsynaptic currents (eEPSCs).

Biochem./physiol. Wirkung

7,8-Dihydroxyflavone (7,8-DHF) may be used to help identify and differentiate the physiological effects and cell signaling pathways mediated by TrkB activation, such as those involving, memory, vasorelaxation and hypertension. 7,8-DHF elicits protection in scopolamine induced Alzheimer-like pathologic dysfunction.

7,8-Dihydroxyflavone is a selective TrkB receptor agonist

7,8-Dihydroxyflavone is a selective tyrosine kinase receptor B (TrkB) receptor agonist. It manifests all the therapeutic effects of brain-derived neurotrophic factor (BDNF)—such as protecting neurons from apoptosis, inhibiting kainic acid-induced toxicity, decreasing infarct volumes in stroke, and neuroprotecting in an animal model of Parkinson′s disease—without the poor pharmacokinetic profile of BDNF limiting its therapeutic potential.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable