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465119

Sigma-Aldrich

Baicalein

98%

Synonym(e):

5,6,7-Trihydroxy-flavon

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About This Item

Empirische Formel (Hill-System):
C15H10O5
CAS-Nummer:
491-67-8
Molekulargewicht:
270.24
Beilstein:
272683
MDL-Nummer:
MFCD00017459
UNSPSC-Code:
12352100
PubChem Substanz-ID:
24870246
NACRES:
NA.22

Assay

98%

Form

solid

mp (Schmelzpunkt)

256-271 °C (lit.)

SMILES String

Oc1cc2OC(=CC(=O)c2c(O)c1O)c3ccccc3

InChI

1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H

InChIKey

FXNFHKRTJBSTCS-UHFFFAOYSA-N

Angaben zum Gen

mouse ... Hexa(15211)
rat ... Alox15(81639) , Alox5(25290)

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Allgemeine Beschreibung

Baicalein, a flavonoid, is a xanthine oxidase inhibitor. Anti-inflammatory effects of baicalein in peripheral human leukocytes has been studied.

Anwendung

Baicalein was used in a study to investigate the in vitro quantitative inhibition of lipoxygenase.

Biochem./physiol. Wirkung

The flavonoid component of Nepalese and Sino-Japanese crude drugs. Baicalein, a major flavone of Scutellariae baicalensis, inhibits the 12-lipoxygenase (12-LOX) pathway of arachidonic acid metabolism, which inhibits cancer cell proliferation and induces apoptosis.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Candidone ≥95% (LC/MS-ELSD)

Sigma-Aldrich

SMB00135

Candidone

Scutellarein ≥98% (HPLC)

Sigma-Aldrich

S0327

Scutellarein

Chrysin ≥96.5%

Sigma-Aldrich

C80105

Chrysin

Wogonin hydrate ≥98% (HPLC), solid

Sigma-Aldrich

W0769

Wogonin hydrate

Nina M Høyland-Kroghsbo et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(1), 131-135 (2016-11-17)
CRISPR-Cas are prokaryotic adaptive immune systems that provide protection against bacteriophage (phage) and other parasites. Little is known about how CRISPR-Cas systems are regulated, preventing prediction of phage dynamics in nature and manipulation of phage resistance in clinical settings. Here
Yefei Zhou et al.
Poultry science, 98(7), 2790-2799 (2019-02-20)
Baicalein, the main flavonoid extracted from the root of Scutellaria baicalensis Georgi, has been demonstrated to exert multiple pharmacological effects, and thus could be utilized as a potential feed additive in broiler chickens. This study evaluated the effects of broiler
D E Shieh et al.
Anticancer research, 20(5A), 2861-2865 (2000-11-04)
Xanthine oxidase inhibitors are known to be therapeutically useful for the treatment of hepatitis and brain tumor. Baicalein, baicalin and wogonin, isolated from Scutellaria rivularis, have been reported to exhibit a strong activity on xanthine oxidase inhibition. In this study
Naheed Riaz et al.
Phytochemistry, 65(8), 1129-1135 (2004-04-28)
Paeoninol and paeonin C, oligostilbene and monoterpene galactoside, have been isolated from the methanolic extract of the fruits of Paeonia emodi. Their structures have been assigned on the basis of spectral analysis including 1D and 2D NMR techniques. In addition
Yuh-Chiang Shen et al.
European journal of pharmacology, 465(1-2), 171-181 (2003-03-26)
To evaluate the possible mechanisms responsible for the anti-inflammatory effects of baicalin or baicalein, phorbol-12-myristate-13-acetate (PMA)- or N-formyl-methionyl-leucyl-phenylalanine (fMLP)-activated inflammatory responses of peripheral human leukocytes were studied. Both baicalin and baicalein diminished fMLP- or PMA-induced reactive oxygen intermediates production in
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