D3071

Dipeptidyl Peptidase IX human

recombinant, expressed in Sf9 cells

• UNSPSC-Code: 12352204
• NACRES: NA.54

Eigenschaften

• Rekombinant: expressed in Sf9 cells
• Qualitätsniveau: 200
• Form: solution
• Spezifische Aktivität: ≥250 units/μg protein
• Versandbedingung: dry ice
• Lagertemp.: −70°C

Beschreibung

Anwendung

DPP9 is a protease of the DPP4 gene family that is used in cancer research to study the regulation of survival and proliferation pathways. DPP9 is used to study cell-extracellular matrix interactions and tissue remodeling.

Biochem./physiol. Wirkung

DPP IX is a member of the S9b family of dipeptidyl peptidases and cleaves the peptide hormones glucagon-like peptide-1, glucagon-like peptide-2, neuropeptide Y and peptide YY with marked kinetic differences compared with dipeptidyl peptidase IV. It has a role in regulating cell survival and proliferation through modulating molecular signaling cascades. Protein kinase B activation is significantly inhibited by human DPP9 overexpression in human hepatoma cells (HepG2 and Huh7) and human embryonic kidney cells (HEK293T). DPP9 is thought to influence cell-extracellular matrix interactions and may be involved in the regulation of tissue remodeling .

Physikalische Eigenschaften

Full length sequence with an N-terminal GST tag

Einheitendefinition

DPP IX is a member of the S9b family of dipeptidyl peptidases. and cleaves the peptide hormones glucagon-like peptide-1, glucagon-like peptide-2, neuropeptide Y and peptide YY with marked kinetic differences compared with dipeptidyl peptidase IV.

One unit will hydrolyze 1.0 picomole of H-Gly-Pro-AMC per minute at pH 7.5 at 25 deg °C

Physikalische Form

Supplied as a solution in 40 mM Tris-HCl pH 8.0, 110 mM NaCl, 2.2 mM KCl, 20% glycerol, 3 mM DTT, and 16 mM glutathione

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1