C4749
Carboxylesterase 2 human
recombinant, expressed in mouse NSO cells, ≥95% (SDS-PAGE)
Synonym(e):
CES2, CES2A1
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About This Item
Empfohlene Produkte
Rekombinant
expressed in mouse NSO cells
Qualitätsniveau
Assay
≥95% (SDS-PAGE)
Form
solution
Spezifische Aktivität
≥1.0 EU/μg
30,000 pmol/min-μg protein
Mol-Gew.
predicted mol wt ~60 kDa
Konzentration
0.4-0.6 mg/mL
Verunreinigungen
≤1.0 EU/μg endotoxin
Versandbedingung
dry ice
Lagertemp.
−70°C
Angaben zum Gen
human ... CES2(8824)
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Biochem./physiol. Wirkung
Human carboxylesterase 2 (hCE-2) recognizes a substrate with a large alcohol group and small acyl group. Its substrate specificity may be restricted by a capability of acyl-hCE-2 conjugate formation due to the presence of conformational interference in the active site pocket. Carboxylesterases catalyze the biotransformation of several ester-containing drugs and prodrugs such as angiotensin-converting enzyme inhibitor (temocarpil, cilazapril), anti-tumor drugs (capecitabin) and narcotics.
Member of a serine esterase family that hydrolyze ester and amide bonds. Carboxylesterase 2 is an endoplasmic reticulum-bound hydrolase that plays a critical role in xenobiotic detoxification and activation for ester-containing therapeutics. Carboxylesterase 2 is also involved in the detoxification of drugs such as heroin and cocaine. This enzyme is thought to play a role in lipid metabolism.
Einheitendefinition
One unit will cause the hydrolysis of 1 picomole of p-nitrophenylacetate per minute at pH 7.5 at 25 deg C.
Physikalische Form
Supplied as a solution containing sodium chloride, sodium acetate, and 20% glycerol.
Signalwort
Danger
H-Sätze
P-Sätze
Gefahreneinstufungen
Resp. Sens. 1
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
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