E0287
Carboxylesterase 1 isoform b human
recombinant, expressed in baculovirus infected BTI insect cells
Synonym(e):
Carboxylesterase 1 human, carboxylesterase, esterase
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About This Item
Rekombinant
expressed in baculovirus infected BTI insect cells
Qualitätsniveau
Form
liquid
Spezifische Aktivität
≥500 units/mg protein
Konzentration
5 mg/mL
Gewicht
(0.5 ml)
Versandbedingung
dry ice
Lagertemp.
−70°C
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Allgemeine Beschreibung
Carboxylesterase (CE) belongs to serine hydrolase family. It is widely present in the human body. Five isoforms of carboxylesterase is present in humans. It is encoded by CES1 gene mapped to 16q22.2 in human chromosome.
Carboxylesterase 1 is a member of a large multigene carboxylesterase family. These enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. This enzyme is known to hydrolyze aromatic and aliphatic esters and is necessary for cellular cholesterol esterification. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds.
Anwendung
Carboxylesterase 1 isoform b human has been used in the reaction to convert Amplex red to resorufin in horse radish peroxidase and oxygen independent manner. It has also been used in the development of an emission ratiometric two-photon probe (SE1) for quantitation in situ.
Delivers high catalytic activity, ideal for robust high-throughput screening assays including drug-drug interaction studies, and pharmacokinetic studies for evaluating pro-drugs and non-CYP pathways of elimination.
Biochem./physiol. Wirkung
Carboxylesterase (CE) is implicated in drug metabolism in liver and hepatic steatosis. Deficiency of CE in humans causes obesity, hyperlipidemia, insulin insensitivity, and cancer.
Einheitendefinition
One unti will hydrolyze one nanomole of 4-nitrophenyl acetate per minute at pH 7.4 at 37°C
Signalwort
Danger
H-Sätze
P-Sätze
Gefahreneinstufungen
Resp. Sens. 1
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
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