A6671

Actinonin

≥98% (TLC), powder, leucine aminopeptidase inhibitor

• Synonym(e): 3-[[1-[(2-(Hydroxymethyl)-1-pyrrolidinyl)carbonyl]-2-methylpropyl]carbamoyl]octanohydroxamic acid
• Empirische Formel (Hill-System): C₁₉H₃₅N₃O₅
• CAS-Nummer: 13434-13-4
• Molekulargewicht: 385.50
• Beilstein: 1555250
• MDL-Nummer: MFCD00080257
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278232
• NACRES: NA.77

Eigenschaften

• product name: Actinonin,
• Biologische Quelle: synthetic (organic)
• Qualitätsniveau: 200
• Assay: ≥98% (TLC)
• Form: powder
• Löslichkeit: ethanol: 50 mg/mL, clear, colorless
• Wirkungsspektrum von Antibiotika: Gram-negative bacteria; Gram-positive bacteria
• Wirkungsweise: enzyme | inhibits
• Lagertemp.: −20°C
• SMILES String: CCCCCC(CC(=O)NO)C(=O)NC(C(C)C)C(=O)N1CCCC1CO
• InChI: 1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)
• InChIKey: XJLATMLVMSFZBN-UHFFFAOYSA-N
• Angaben zum Gen: human ... ANPEP(290) , DPP4(1803) , ECE1(1889) , LAP3(51056)

Beschreibung

Allgemeine Beschreibung

Chemical structure: peptide

Anwendung

Actinonin has been used as a control to inhibit meprin-β activity in C57BL/6 mice. It has also been used to study the high-affinity interaction of EcPDF with actinonin by 15N NMR spectroscopy and isothermal titration.

Biochem./physiol. Wirkung

Actinonin has inhibitory action against peptide deformylase (PDF). It is effective against Gram-positive and fastidious Gram-negative microorganisms.

Actinonin is an inhibitor of leucine aminopeptidase. Actinonin has also been used to improve antibacterial activity and antiobesity therapeutics.

Leistungsmerkmale und Vorteile

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)