A6476

ABT-418 hydrochloride

powder, ≥98% (HPLC)

• Synonym(e): 3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride
• Empirische Formel (Hill-System): C₉H₁₄N₂O · HCl
• CAS-Nummer: 147388-83-8
• Molekulargewicht: 202.68
• MDL-Nummer: MFCD11045960
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 24724395
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Löslichkeit: H₂O: soluble 15 mg/mL
• Ersteller: Abbott
• SMILES String: Cl.CN1CCC[C@H]1c2cc(C)no2
• InChI: 1S/C9H14N2O.ClH/c1-7-6-9(12-10-7)8-4-3-5-11(8)2;/h6,8H,3-5H2,1-2H3;1H/t8-;/m0./s1
• InChIKey: VOXHERKWAIEJQF-QRPNPIFTSA-N

Beschreibung

Allgemeine Beschreibung

ABT-418 is an α4β2 agonist of nicotinic receptors.

Anwendung

ABT-418 [(S)-3-methyl-5-(1 methyl-2-pyrrolidinyl)isoxazole hydrochloride] is a novel neuronal nicotinic acetylcholine receptor (nAChR) ligand with cognitive enhancing and anxiolytic-like activity 3- to 10-fold more potent than (-)-nicotine in rodents. ABT-418 hydrochloride has been used to study new therapeutic approaches for the treatment of Alzheimer′s disease.

ABT-418 hydrochloride has been used as a nicotinic acetylcholine receptor (nAChR) agonist to test its effect on spatial memory improvement in attention deficit hyperactivity disorder (ADHD) rat model

Biochem./physiol. Wirkung

Neuronal nicotinic acetylcholine receptor agonist with cognition enhancing and anxiolytic activities.

Leistungsmerkmale und Vorteile

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Rechtliche Hinweise

Subject to U.S. Patent No. 5409946 and sold under license from Abbott Laboratories.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H300 + H310 + H330
• P-Sätze: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Gefahreneinstufungen: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable