A3509

2-Aminopurin

≥99%

• Synonym(e): 2-AP
• Empirische Formel (Hill-System): C₅H₅N₅
• CAS-Nummer: 452-06-2
• Molekulargewicht: 135.13
• EG-Nummer: 207-197-4
• MDL-Nummer: MFCD00005566
• UNSPSC-Code: 41106305
• PubChem Substanz-ID: 24890778
• NACRES: NA.51

Eigenschaften

• Biologische Quelle: synthetic
• Assay: ≥99%
• Form: powder
• mp (Schmelzpunkt): 280-282 °C (lit.)
• Lagertemp.: 2-8°C
• SMILES String: Nc1ncc2[nH]cnc2n1
• InChI: 1S/C5H5N5/c6-5-7-1-3-4(10-5)9-2-8-3/h1-2H,(H3,6,7,8,9,10)
• InChIKey: MWBWWFOAEOYUST-UHFFFAOYSA-N

Beschreibung

Anwendung

2-Aminopurine (2-AP) is used to specifically inhibit double-stranded RNA-dependent protein kinase, protein kinase R (PKR).

2-Aminopurine has been used to inhibit eukaryotic initiation factor-2α (eIF2α)-phosphorylation of osteoarthritis (OA) chondrocytes.

Biochem./physiol. Wirkung

2-Aminopurine (2AP) is an analog of guanosine and adenosine, which can base pair with cytosine and thymine. It is used as a fluorescent probe in nucleic acid structure and dynamics. 2-Aminopurine (2-AP) inhibits double-stranded RNA-dependent protein kinase, protein kinase R (PKR).

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves