88185

Tetrazol -Lösung

suitable for DNA synthesis, filtered through a 1 μm filter, ~0.45 M in acetonitrile

• Synonym(e): 1H-Tetrazole
• Empirische Formel (Hill-System): CH₂N₄
• CAS-Nummer: 288-94-8
• Molekulargewicht: 70.05
• Beilstein: 105799
• MDL-Nummer: MFCD00005247
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 57653295
• NACRES: NA.21
• bp: 84 °C (lit.)

Eigenschaften

• Form: liquid
• Qualitätsniveau: 300
• Qualität: filtered through a 1 μm filter
• Konzentration: ~0.45 M in acetonitrile
• Methode(n): DNA synthesis: suitable
• Verunreinigungen: ≤0.003% water
• bp: 84 °C (lit.)
• mp (Schmelzpunkt): 156-158 °C (lit.)
• Dichte: 0.798 g/mL at 20 °C
• SMILES String: c1nnn[nH]1
• InChI: 1S/CH2N4/c1-2-4-5-3-1/h1H,(H,2,3,4,5)
• InChIKey: KJUGUADJHNHALS-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

The product is ~0.45M solution of tetrazole in acetonitrile. Tetrazole ring plays significant role in various synthetic and industrial processes.

Anwendung

Tetrazole solution is useful for DNA synthesis. It may be employed as a catalyst for the in situ synthesis of deoxyribonucleoside phosphoramidites. It may be used in the preparation of following anionic nucleotide-lipids:

• thymidine 3′-(1,2-dilauroyl-sn-glycero-3-phosphate) , diC₁₂-3′-dT
• thymidine 3′-(1,2-dimyristoyl-sn-glycero-3-phosphate) diC₁₄- 3′-dT
• thymidine-3′-(1,2-dipalmitoyl-sn-glycero-3-phosphate) diC₁₆- 3′-dT

Vorsicht

Bei Raumtemperatur gesättigte Lösung. Beim Lagern unterhalb Raumtemperatur kann ein Niederschlag auftreten.

Sonstige Hinweise

Catalyst used in the phosphite triester method of oligonucleotide synthesis for the coupling of (dialkylamino)phosphines

Sicherheitshinweise

• Piktogramme: GHS02,GHS07
• Signalwort: Danger
• H-Sätze: H225,H302 + H312 + H332,H319
• P-Sätze: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 3
• Flammpunkt (°F): 41.0 °F - closed cup
• Flammpunkt (°C): 5 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter