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Y0001373

Nicergolin

European Pharmacopoeia (EP) Reference Standard

Synonym(e):

5-Brom-nicotinsäure-10-methoxy-1,6-dimethylergolin-8-methylester

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About This Item

Empirische Formel (Hill-System):
C24H26BrN3O3
CAS-Nummer:
27848-84-6
Molekulargewicht:
484.39
MDL-Nummer:
MFCD00869626
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329831388
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

nicergoline

Hersteller/Markenname

EDQM

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

[H][C@@]12Cc3cn(C)c4cccc(c34)[C@]1(C[C@@H](COC(=O)c5cncc(Br)c5)CN2C)OC

InChI

1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1

InChIKey

YSEXMKHXIOCEJA-FVFQAYNVSA-N

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Nicergoline EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Verpackung

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Sonstige Hinweise

Sales restrictions may apply.

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Beschreibung
Preisangaben

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number

Leider sind derzeit keine COAs für dieses Produkt online verfügbar.

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Die Dokumentenbibliothek aufrufen

A Moretti
Arzneimittel-Forschung, 29(8a), 1213-1223 (1979-01-01)
The effects of 10-methoxy-1,6-dimethyl-ergoline-8 beta-methanol(5-bromonicotinate) (nicergoline, Sermion) on the energy metabolism in the animal CNS during and after cerebral hypoxia and ischemia have been studied by various authors by different methodological approaches. For this purpose both electrophysiological (EEG and cortically
Treatment of impaired cognition with nootropic drugs: nicergoline versus the state of the art.
R G Fariello
Functional neurology, 12(3-4), 221-225 (1997-05-01)
M Fioravanti et al.
The Cochrane database of systematic reviews, (4)(4), CD003159-CD003159 (2001-11-01)
Nicergoline is an ergot derivative currently in use in over fifty countries for more than three decades, for the treatment of cognitive, affective, and behavioral disorders of older people. It was initially considered as a vasoactive drug and mainly prescribed
Bengt Winblad et al.
Clinical drug investigation, 28(9), 533-552 (2008-08-01)
The ergot alkaloid derivative nicergoline became clinically available about 35 years ago in the 1970s. Nicergoline has a broad spectrum of action: (i) as an alpha(1)-adrenoceptor antagonist, it induces vasodilation and increases arterial blood flow; (ii) it enhances cholinergic and
A Moretti et al.
Arzneimittel-Forschung, 29(8a), 1223-1227 (1979-01-01)
10-Methoxy-1,6-dimethyl-ergoline-8 beta-methanol-(5-bromonicotinate) (nicergoline, Sermion) shows a strong alpha-blocking activity both in vitro and in vivo. Various studies (dog, cat, rabbit, rat, mouse, guinea-pig) show that nicergoline affects only slightly blood pressure and heart rate and increases the blood flow in
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