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Merck

PHR1094

Supelco

Phenacetin Schmelzpunktstandard

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(e):

Phenacetin, 1-Acetamino-4-ethoxy-benzol, 4′-Ethoxyacetanilid, N-(4-Ethoxyphenyl)-acetamid, p-Acetophenetidid, Acetophenetidin

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About This Item

Lineare Formel:
CH3CONHC6H4OC2H5
CAS-Nummer:
Molekulargewicht:
179.22
Beilstein:
1869238
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

Agentur

traceable to USP 1514008

API-Familie

phenacetin

Analysenzertifikat (CofA)

current certificate can be downloaded

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

mp (Schmelzpunkt)

~Approximately 135 °C
133-136 °C (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

CCOc1ccc(NC(C)=O)cc1

InChI

1S/C10H13NO2/c1-3-13-10-6-4-9(5-7-10)11-8(2)12/h4-7H,3H2,1-2H3,(H,11,12)

InChIKey

CPJSUEIXXCENMM-UHFFFAOYSA-N

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Allgemeine Beschreibung

Phenacetin is a mild analgesic drug effective for the treatment of mild to moderate pain. Its analgesic property is comparable to that of aspirin.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Anwendung

Phenacetin may be used as a calibration standard for the development of a test for the evaluation of phenacetin by thermal analyzes methods.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem./physiol. Wirkung

Substrat von CYP1A2 und CYP2D6

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAC4010 in the slot below. This is an example certificate only and may not be the lot that you receive.

Empfohlene Produkte

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Piktogramme

Health hazardExclamation mark

Signalwort

Danger

H-Sätze

Gefahreneinstufungen

Acute Tox. 4 Oral - Carc. 1B

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Analysenzertifikate (COA)

Lot/Batch Number

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Kunden haben sich ebenfalls angesehen

Broad range purity analysis by melting point depression using a singular feature common to all DSC purity scans
Gustin GM
Thermochimica Acta, 39(2), 81-93 (1980)
Paracetamol and phenacetin
Clissold SP
Drugs, 32(4), 46-59 (1986)
Purity and heat of fusion data for environmental standards as determined by differential scanning calorimetry
Donnelly JR, et al.
Thermochimica Acta, 167(2), 155-187 (1990)
J A Hinson
Environmental health perspectives, 49, 71-79 (1983-03-01)
Phenacetin can be metabolized to reactive metabolites by a variety of mechanisms. (1) Phenacetin can be N-hydroxylated, and the resulting N-hydroxyphenacetin can be sulfated or glucuronidated. Whereas phenacetin N-O sulfate immediately rearranges to form a reactive metabolite which may covalently
L F Prescott
British journal of clinical pharmacology, 10 Suppl 2, 291S-298S (1980-10-01)
1 The rate of absorption of oral paracetamol depends on the rate of gastric emptying and is usually rapid and complete. The mean systemic availability is about 75%. 2 Paracetamol is extensively metabolized and the plasma half-life is 1.5-2.5 hours.

Protokolle

US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)

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