45674

Erythromycin

tested according to Ph. Eur.

• Synonym(e): Erythromycinum
• Empirische Formel (Hill-System): C₃₇H₆₇NO₁₃
• CAS-Nummer: 114-07-8
• Molekulargewicht: 733.93
• Beilstein: 75279
• EG-Nummer: 204-040-1
• MDL-Nummer: MFCD00084654
• UNSPSC-Code: 51101500
• PubChem Substanz-ID: 329756889
• NACRES: NA.76

Eigenschaften

• Agentur: EPA 1694; USP/NF; tested according to Ph. Eur.
• Qualitätsniveau: 200
• Form: solid
• Farbe: white to faint yellow
• Löslichkeit: H₂O: soluble 2 mg/mL; acetone: freely soluble; acetonitrile: freely soluble; alcohol: soluble; amyl acetate: moderately soluble; chloroform: soluble; diethyl ether: soluble; ethyl acetate: freely soluble
• Wirkungsspektrum von Antibiotika: Gram-negative bacteria; Gram-positive bacteria
• Anwendung(en): environmental
• Wirkungsweise: protein synthesis | interferes
• SMILES String: CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
• InChI: 1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1
• InChIKey: ULGZDMOVFRHVEP-RWJQBGPGSA-N
• Angaben zum Gen: human ... ABCB1(5243) , CYP3A4(1576) , MLNR(2862) ; mouse ... Abcb1a(18671) , Abcb1b(18669)

Beschreibung

Allgemeine Beschreibung

Chemical structure: macrolide

Anwendung

Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro††, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.

Biochem./physiol. Wirkung

Wirkungsweise: Inhibiert Elongation bei dem Transpepditierungsschritt.
Antimikrobielles Spektrum: Gram-negative und Gram-positive Bakterien.

Verpackung

25g

Vorsicht

This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.

Angaben zur Herstellung

This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)