17929

O-Methyl-O′-succinylpolyethylenglycol 5′000

• Synonym(e): O-(Succinyl)-O-methylpolyethylenglykol 5′000, Polyethylenglykol 5′000 monomethylether-succinat
• Lineare Formel: CH₃O(CH₂CH₂O)_nCOCH₂CH₂COOH
• CAS-Nummer: 31961-02-1
• MDL-Nummer: MFCD00284260
• UNSPSC-Code: 51171641
• NACRES: NA.26

Eigenschaften

• Form: powder
• Mol-Gew.: M_r ~5100
• mp (Schmelzpunkt): 56-60 °C
• Ω-Ende: carboxylic acid
• α-Ende: methoxy
• Lagertemp.: −20°C

Beschreibung

Anwendung

Polyethylene glycol 5000 is used in the construction of biomaterials such as biopolymers, micelles and nanostructures.

Soluble polymer for solid phase synthesis of imines and β-lactams; attaching peptides to PEG

Biochem./physiol. Wirkung

O-Methyl-O′-succinylpolyethylene glycol 5′000 is a modified monomethoxypolyethylene glycol (mPEG) wherein the hydroxyl groups are succinylated by succinic anhydride. This succinylated mPEG can then be used to synthesize tolerogenic mPEG conjugates of peptides. Tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves