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202487

Sigma-Aldrich

Poly(ethylenglycol)methylether

average MN 550, methoxy, hydroxyl

Synonym(e):

Methoxy-polyethylenglykol, Polyethylenglykol-monomethylether, mPEG

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About This Item

Lineare Formel:
CH3(OCH2CH2)nOH
CAS-Nummer:
9004-74-4
MDL-Nummer:
MFCD00084416
UNSPSC-Code:
12162002
PubChem Substanz-ID:
24852066
NACRES:
NA.23

Produktbezeichnung

Poly(ethylenglycol)methylether, average Mn 550

Dampfdichte

>1 (vs air)

Dampfdruck

0.05 mmHg ( 20 °C)

Form

semisolid

Mol-Gew.

average Mn 550

Brechungsindex

n20/D 1.455

Viskosität

7.5 cSt(210 °F)(lit.)

Übergangstemp.

Tm 20 °C

Dichte

1.089 g/mL at 25 °C

Ω-Ende

hydroxyl

α-Ende

methoxy

SMILES String

O(CCO)C

InChI

1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3

InChIKey

XNWFRZJHXBZDAG-UHFFFAOYSA-N

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Anwendung

Poly(ethylenglykol)methylether kann als Porenbildungsmittel zum Herstellen von Polysulfonmembranen mit verbesserter Hydrophilie eingesetzt werden.

Poly(ethylenglykol)methylether-transplantierte Polyamidoamin (PAMAM)-Dendrimere können als Arzneimittelträgersysteme für Antikrebsmittel verwendet werden.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

359.6 °F - closed cup

Flammpunkt (°C)

182 °C - closed cup

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
MKCN8241
MKCL2387
MKCH8837
MKCF0413
MKCB0160V

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Polyethylene glycol dimethyl ether 500 (stabilised) for synthesis

Sigma-Aldrich

8.14171

Polyethylene glycol dimethyl ether 500

Smita K Pawar et al.
International journal of pharmaceutics, 436(1-2), 183-193 (2012-06-23)
Efficacy of anticancer drug is limited by the severe adverse effects induced by drug; therefore the crux is in designing delivery systems targeted only to cancer cells. Toward this objectives, we propose, synthesis of poly(ethylene glycol) (PEG)-doxorubicin (DOX) prodrug conjugates
Mark G P Saifer et al.
Molecular immunology, 57(2), 236-246 (2013-11-10)
The use of methoxypoly(ethylene glycol) (mPEG) in PEG conjugates of proteins and non-protein therapeutic agents has led to the recognition that the polymer components of such conjugates can induce anti-PEG antibodies (anti-PEGs) that may accelerate the clearance and reduce the
Jiani Zheng et al.
Langmuir : the ACS journal of surfaces and colloids, 28(37), 13261-13273 (2012-08-28)
Alginate/chitosan/alginate (ACA) hydrogel microcapsules were modified with methoxy poly(ethylene glycol) (MPEG) to improve protein repellency and biocompatibility. Increased MPEG surface graft density (n(S)) on hydrogel microcapsules was achieved by controlling the grafting parameters including the buffer layer substrate, membrane thickness
Mulu Z Tesfay et al.
Journal of virology, 87(7), 3752-3759 (2013-01-18)
We are developing oncolytic vesicular stomatitis viruses (VSVs) for systemic treatment of multiple myeloma, an incurable malignancy of antibody-secreting plasma cells that are specifically localized in the bone marrow. One of the presumed advantages for using VSV as an oncolytic
Seung-Young Lee et al.
Biomaterials, 34(2), 552-561 (2012-10-20)
Although targeted delivery mediated by ligand modified or tumor microenvironment sensitive nanocarriers has been extensively pursued for cancer chemotherapy, the efficiency is still limited by premature drug release after systemic administration. Herein we report a highly blood-stable, tumor-adaptable drug carrier
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Artikel

Fouling Resistant Biomimetic Poly(Ethylene Glycol) Based Grafted Polymer Coatings

Fouling Resistant Biomimetic Poly(Ethylene Glycol) Based Grafted Polymer Coatings

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Versatile Cell Culture Scaffolds via Bio-orthogonal Click Reactions

Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

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