422706

KN-62

A cell-permeable, reversible, and selective inhibitor of CaM kinase II (K_i = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme.

• Synonym(e): KN-62, 1-[N,O- bis-(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, P2X Antagonist II, Purinergic Receptor P2X Antagonist II, 1-[N,O-bis-(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, P2X Antagonist II, Purinergic Receptor P2X Antagonist II
• Empirische Formel (Hill-System): C₃₈H₃₅N₅O₆S₂
• CAS-Nummer: 127191-97-3
• Molekulargewicht: 721.84
• MDL-Nummer: MFCD00083180
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated; protect from light
• Farbe: off-white
• Löslichkeit: methanol: 5 mg/mL; DMSO: soluble
• Versandbedingung: ambient
• Lagertemp.: 2-8°C
• InChI: 1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3
• InChIKey: RJVLFQBBRSMWHX-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable, reversible, and selective inhibitor of Ca²⁺/calmodulin-dependent protein kinase II (K_i = 900 nM for rat brain enzyme) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.

A cell-permeable, reversible, and selective inhibitor of CaM kinase II (K_i = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
cam kinase 2

Product does not compete with ATP.

Reversible: yes

Target K_i: 900 nM for rat brain CaM kinase II

Warnhinweis

Toxicity: Standard Handling (A)

Angaben zur Herstellung

Further dilute with aqueous buffer just prior to use.

Rekonstituierung

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.

Sonstige Hinweise

Minami, H., et al. 1994. Biochem. Biophys. Res. Commun.199, 241.
Kato, M., et al. 1992. Neurosci. Lett.129, 47.
Ishii, A., et al. 1991. Biochem. Biophys. Res. Commun.176, 1051.
Ito, I., et al. 1991. Neurosci. Lett.121, 119.
Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable