422712

KN-93

InSolution, ≥95%, A cell-permeable, competitive inhibitor of Ca²⁺/calmodulin-dependent protein kinase II

• Synonym(e): InSolution KN-93
• Empirische Formel (Hill-System): C₂₆H₂₉ClN₂O₄S
• CAS-Nummer: 139298-40-1
• Molekulargewicht: 501.04
• MDL-Nummer: MFCD03788201
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: liquid
• Wirksamkeit: 370 nM K_i
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated (hygroscopic); protect from light
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• InChI: 1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+
• InChIKey: LLLQTDSSHZREGW-AATRIKPKSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable, competitive inhibitor of Ca²⁺/calmodulin-dependent protein kinase II (K_i = 370 nM). Selectively binds to the Calmodulin (CaM) binding site of the enzyme and prevents the association of CaM with CaM Kinase II. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets. Has no significant effect on protein kinase A activity. Induces G₁ cell cycle arrest and apoptosis in NIH 3T3 cells.

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
cam kinase 2

Product does not compete with ATP.

Reversible: yes

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Irritant (B)

Physikalische Form

A 5 mM (1 mg/399 µl) solution of KN-93 (Cat. No. 422708) in DMSO.

Rekonstituierung

Following initial thaw aliquot and freeze (-20°C).

Sonstige Hinweise

Fan, G.H., et al. 1999. Mol. Pharmacol.56, 39.
Tombes, R.M., et al. 1995. Cell Growth Differentiation6, 1063.
Chen, C., et al. 1994. Science266, 291.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun.195, 608.
Niki, I., et al. 1993. Biochem. Biophys. Res. Commun.191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Flammpunkt (°C): 87 °C - closed cup - (Dimethylsulfoxide)