930660

Pomalidomide 4′-PEG₃-amine hydrochloride

≥95%

• Synonym(e): 1H-Isoindole-1,3(2H)-dione hydrochloride, 4-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethylamino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione hydrochloride, 4-[[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl) hydrochloride
• Empirische Formel (Hill-System): C₂₁H₂₈N₄O₇ · xHCl
• CAS-Nummer: 2446474-09-3
• Molekulargewicht: 448.47 (free base basis)
• MDL-Nummer: MFCD32063491
• UNSPSC-Code: 12352116
• NACRES: NA.21

Eigenschaften

• ligand: pomalidomide
• Qualitätsniveau: 100
• Assay: ≥95%
• Form: powder
• Funktionelle Gruppe: amine
• Lagertemp.: 2-8°C
• SMILES String: O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCOCCOCCOCCN)=CC=C3)=O)=O

Beschreibung

Anwendung

Pomalidomide 4′-PEG₃-amine Hydrochloride is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Allows rapid conjugation with carboxyl linkers due to the presence of an amine group via peptide coupling reactions. It is also active for linker attachment via reductive amination, and a basic building block for development of a protein degrader library.


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Rechtliche Hinweise

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable