795682

(4R,4′R,5S,5′S)-2,2′-(1-Methylethylidene

95%

• Synonym(e): 2,2-Bis[2-(4R,5S-diphenyl-1,3-oxazolinyl)]propane
• Empirische Formel (Hill-System): C₃₃H₃₀N₂O₂
• CAS-Nummer: 157904-67-1
• Molekulargewicht: 486.60
• MDL-Nummer: MFCD24849939
• UNSPSC-Code: 12352005
• PubChem Substanz-ID: 329768502
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: 95%
• Form: solid
• mp (Schmelzpunkt): 164-169 °C
• SMILES String: CC(C1=N[C@H](C2=CC=CC=C2)[C@H](C3=CC=CC=C3)O1)(C)C4=N[C@H](C5=CC=CC=C5)[C@H](C6=CC=CC=C6)O4
• InChI: 1S/C33H30N2O2/c1-33(2,31-34-27(23-15-7-3-8-16-23)29(36-31)25-19-11-5-12-20-25)32-35-28(24-17-9-4-10-18-24)30(37-32)26-21-13-6-14-22-26/h3-22,27-30H,1-2H3/t27-,28-,29+,30+/m1/s1
• InChIKey: ZWWGNCSTEMMQOQ-XAZDILKDSA-N

Beschreibung

Anwendung

(4R,4′R,5S,5′S)-2,2′-(1-Methylethylidene) or (4S,5R)-Bis-Phbox) can be used as a ligand:

• To prepare selective exo-catalysts for enantioselective 1,3-dipolar cycloaddition reactions.
• In the asymmetric aminooxygenation of alkenes in the presence of tetramethylaminopyridyl radical (TEMPO) as an oxidant and copper(II) triflate as a catalyst.
• In asymmetric aminofluorination of olefins using an iron catalyst.

This chiral Box ligand was most recently shown to mediate an asymmetric aminofluorination of olefins utlizing Xtalfuor-E (719439) and TREAT-HF (344648). The resulting cyclic carbamates can be readily converted into their concomitant beta-fluoro amino acids.

Sonstige Hinweise

Iron(II)-Catalyzed Intramolecular Olefin Aminofluorination

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable