776874

K-Oxyma

97%

• Synonym(e): 2-Cyano-2-(hydroxyimino)acetic acid ethyl ester, potassium salt, Ethyl (hydroxyimino)cyanoacetate potassium salt
• Empirische Formel (Hill-System): C₅H₅KN₂O₃
• CAS-Nummer: 158014-03-0
• Molekulargewicht: 180.20
• MDL-Nummer: MFCD26960809
• UNSPSC-Code: 12352111
• PubChem Substanz-ID: 329767868
• NACRES: NA.22

Eigenschaften

• Assay: 97%
• Form: powder
• Eignung der Reaktion: reaction type: Addition Reactions
• mp (Schmelzpunkt): 141-147
• Anwendung(en): peptide synthesis
• Lagertemp.: 2-8°C
• SMILES String: CCOC(/C(C#N)=N/[O-])=O.[K+]
• InChI: 1S/C5H6N2O3.K/c1-2-10-5(8)4(3-6)7-9;/h9H,2H2,1H3;/q;+1/p-1/b7-4+;
• InChIKey: ZFBMUWGNRJITLS-KQGICBIGSA-M

Beschreibung

Anwendung

• Non-explosive replacement for HOBt and HOAt with at least comparable performance to HOAt
• Outperforms HOAt in sterically demanding peptide bond formations
• Compatible with carbodiimide-mediated; solution and solid phase peptide coupling;
• Less epimerization than HOBt in fragment condensation reactions
• K-salt especially useful in peptide coupling on mild acid-labile resins such as 2-chlorotrityl; leading to minimal to no cleavage of the peptide from the resin due to its more alkaline character
• K-salt has a higher melting point than OxymaPure

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable