630721

6-Aminoindol

97%

• Synonym(e): Indol-6-ylamine, NSC 82379
• Empirische Formel (Hill-System): C₈H₈N₂
• CAS-Nummer: 5318-27-4
• Molekulargewicht: 132.16
• MDL-Nummer: MFCD02093959
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24882337
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: 97%
• Form: solid
• mp (Schmelzpunkt): 75-79 °C
• Lagertemp.: −20°C
• SMILES String: Nc1ccc2cc[nH]c2c1
• InChI: 1S/C8H8N2/c9-7-2-1-6-3-4-10-8(6)5-7/h1-5,10H,9H2
• InChIKey: MIMYTSWNVBMNRH-UHFFFAOYSA-N

Beschreibung

Anwendung

Reactant for preparation of:

• Inhibitors of mammalian target of rapamycin (mTOR ) protein
• Inhibitors of the AcrAB-TolC efflux pump
• Inhibitors of Gli1-mediated transcription in the Hedgehog pathway
• Potent DNA-topoisomerase II poisons and anti-MDR agents
• Protein kinase C θ (PKCθ) inhibitors
• Piperidine carboxamide as transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonists
• Potent and selective blockers of the Nav1.8 sodium channel as potential analgesics for the treatment of neuropathic and inflammatory pain
• 5,6-fused heteroaromatic ureas as TRPV1 antagonists
• Allosteric enhancers of the A3 adenosine receptor
• Human liver glycogen phosphorylase (HLGP) inhibitors for the treatment of type 2 diabetes

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H315,H319,H335
• P-Sätze: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves