328820

4-Fluorphenylmagnesiumbromid -Lösung

1.0 M in THF

• Synonym(e): p-Fluorophenylmagnesium bromide, Bromo(4-fluorophenyl)magnesium, Bromo(p-fluorophenyl)magnesium
• Lineare Formel: FC₆H₄MgBr
• CAS-Nummer: 352-13-6
• Molekulargewicht: 199.30
• Beilstein: 636802
• MDL-Nummer: MFCD00009667
• UNSPSC-Code: 12352103
• PubChem Substanz-ID: 24859751
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Eignung der Reaktion: reaction type: Grignard Reaction
• Konzentration: 1.0 M in THF
• Dichte: 1.021 g/mL at 25 °C
• Funktionelle Gruppe: fluoro
• SMILES String: Fc1ccc([Mg]Br)cc1
• InChI: 1S/C6H4F.BrH.Mg/c7-6-4-2-1-3-5-6;;/h2-5H;1H;/q;;+1/p-1
• InChIKey: QYBFFRXNNFXREA-UHFFFAOYSA-M

Beschreibung

Anwendung

4-Fluorophenylmagnesium bromide solution (Grignard reagent) can be used as a reagent in the synthesis of:

• Useful key intermediate in the synthesis of paroxetine.
• Arylsulfides via cross-coupling reaction with thiols.
• 4-Arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as androgen receptor antagonists.
• Grignard intermediate for preparing aprepitant.

Sicherheitshinweise

• Piktogramme: GHS02,GHS08,GHS05,GHS07
• Signalwort: Danger
• H-Sätze: H225,H302,H314,H335,H336,H351
• P-Sätze: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
• Zielorgane: Respiratory system
• Zusätzliche Gefahrenhinweise: EUH014,EUH019
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 3
• Flammpunkt (°F): -4.0 °F - closed cup
• Flammpunkt (°C): -20 °C - closed cup
• Persönliche Schutzausrüstung: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter