309567

(Methoxymethyl)triphenylphosphoniumchlorid

97%

• Synonym(e): Triphenyl(methoxymethyl)phosphonium chloride
• Lineare Formel: (C₆H₅)₃P(Cl)CH₂OCH₃
• CAS-Nummer: 4009-98-7
• Molekulargewicht: 342.80
• Beilstein: 3599844
• EG-Nummer: 223-664-5
• MDL-Nummer: MFCD00011800
• UNSPSC-Code: 12352107
• PubChem Substanz-ID: 24858739
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: 97%
• Form: solid
• Eignung der Reaktion: reaction type: C-C Bond Formation
• mp (Schmelzpunkt): 185-195 °C (dec.) (lit.)
• SMILES String: [Cl-].COC[P+](c1ccccc1)(c2ccccc2)c3ccccc3
• InChI: 1S/C20H20OP.ClH/c1-21-17-22(18-11-5-2-6-12-18,19-13-7-3-8-14-19)20-15-9-4-10-16-20;/h2-16H,17H2,1H3;1H/q+1;/p-1
• InChIKey: SJFNDMHZXCUXSA-UHFFFAOYSA-M

Beschreibung

Anwendung

(Methoxymethyl)triphenylphosphonium chloride is a Wittig reagent that reacts with aldehydes and ketones to give substituted alkenes. This Wittig reaction finds application as the key step in the synthesis of:

• Antimalarial drug, (+)-artemisinin.
• Substituted quinolines.
• Akuammiline alkaloid picrinine.
• 7H-pyrrolo[2,3-d]pyrimidine derivatives for signal transducers and activators of transcription 6 (STAT6) inhibitors.

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H302,H315,H319,H411
• P-Sätze: P264 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): >482.0 °F
• Flammpunkt (°C): > 250 °C
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves