SML0762

Enzastaurin

≥98% (HPLC)

• Synonyme(s) : 3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione, D04014, LY-317615, LY317615
• Formule empirique (notation de Hill): C₃₂H₂₉N₅O₂
• Numéro CAS: 170364-57-5
• Poids moléculaire : 515.60
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: , light orange to dark orange-red
• Solubilité: DMSO: 10 mg/mL, clear (warmed)
• Température de stockage: −20°C
• InChI: 1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39)
• Clé InChI: AXRCEOKUDYDWLF-UHFFFAOYSA-N

Description

Application

Enzastaurin has been used in splicing analysis to study its effects on splicing of a mutated exon.

Actions biochimiques/physiologiques

Enzastaurin is a potent and PKCβ preferring inhibitor. Also, Enzastaurin inhibits AKT and GSK3β. Enzastaurin acts as anti-angiogenic and antineoplastic agent.

It is an orally administered drug. It can induce apoptosis, inhibit angiogenesis and proliferation of cells. Enzastaurin can be used for the treatment of haematological cancers.

Caractéristiques et avantages

This compound is featured on the GSK-3, PKB/Akt and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H413
• Conseils de prudence: P273 - P301 + P312 + P330
• Classification des risques: Acute Tox. 4 Oral - Aquatic Chronic 4
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable