SAB4500366
Anti-Collagen II antibody produced in rabbit
affinity isolated antibody
Synonyme(s) :
CO2A1, chondrocalcin, collagen, collagen α-1 (II), type II
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.43
Produits recommandés
Source biologique
rabbit
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
antigen 141 kDa
Espèces réactives
human, mouse, rat
Concentration
~1 mg/mL
Technique(s)
ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... COL2A1(1280)
Catégories apparentées
Description générale
Anti-Collagen II Antibody detects endogenous levels of total Collagen II protein.
Collagen type II α 1 chain (COL2A1) gene is mapped to human chromosome 12q13.11–q13.12. COL2A1 belongs to collagen superfamily. The encoded protein is characterized with three identical α chains forming homotrimers. Collagen II is the major component of cartilage.
Immunogène
The antiserum was produced against synthesized peptide derived from human Collagen II.
Immunogen Range: 101-150
Immunogen Range: 101-150
Application
Anti-Collagen II, N-Terminal antibody produced in rabbit has been used for:
- Western blotting
- Immunofluorescence
- Immunohistological analyses
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (2 papers)
Immunohistochemistry (2 papers)
Actions biochimiques/physiologiques
Mutation of collagen type II α 1 chain (COL2A1), leads to a variety of clinical manifestations such as skeletal dysplasia, short stature, and sensorial defects, collectively known as type II collagenopathies. Function of COL2A1 in articular cartilage is to form highly organized fibers, which are essential for the mechanical properties of the tissue.
Caractéristiques et avantages
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forme physique
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
nwg
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Les clients ont également consulté
Yu Yao et al.
International journal of molecular medicine, 41(1), 173-183 (2017-11-09)
Surgery-obtained synovium specimens (SSSs) can provide a source of synovial mesenchymal stem cells (SMSCs) for experimental studies. However, these specimens contain diverse tissues, including the intima and subintima; therefore, these SMSCs are not entirely derived from the intima and their cell source
Christine I Seidl et al.
Arthritis & rheumatology (Hoboken, N.J.), 68(2), 398-409 (2015-09-12)
To investigate the function of microRNA-138 (miR-138) in human articular chondrocytes (HACs). The expression of miR-138 in intact cartilage and cultured chondrocytes and the effects of miR-138 overexpression on chondrocyte marker genes were investigated. Targets of miR-138 relevant to chondrocytes
E Takahashi et al.
Human genetics, 86(1), 14-16 (1990-11-01)
A new mapping system, based on nonisotopic in situ hybridization combined with fluorescent staining of replicated prometaphase R-bands, is described. Replication of the bands is achieved by treatment of thymidine-synchronized cells with bromodeoxyuridine. The human COL2A1 gene was mapped to
Mouna Barat-Houari et al.
Human mutation, 37(1), 7-15 (2015-10-08)
Mutations in the COL2A1 gene cause a spectrum of rare autosomal-dominant conditions characterized by skeletal dysplasia, short stature, and sensorial defects. An early diagnosis is critical to providing relevant patient care and follow-up, and genetic counseling to affected families. There
Elena V Isaeva et al.
International journal of molecular sciences, 23(5) (2022-03-11)
The aim of this study was to verify the applicability of high-concentration collagen-based bioink with MSC (ADSC) and decellularized ECM granules for the formation of cartilage tissue de novo after subcutaneous implantation of the scaffolds in rats. The printability of
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