E8280

Exo 1

≥98% (HPLC), solid

• Synonyme(s) : 2-(4-Fluorobenzoylamino)benzoic acid methyl ester, 2-(4-Fluorobenzoylamino)methylbenzoate
• Formule empirique (notation de Hill): C₁₅H₁₂NFO₃
• Numéro CAS: 75541-83-2
• Poids moléculaire : 273.26
• Numéro MDL: MFCD00028104
• Code UNSPSC : 12352203
• ID de substance PubChem : 24724477
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Solubilité: DMSO: soluble 19 mg/mL
• Chaîne SMILES: COC(=O)c1ccccc1NC(=O)c2ccc(F)cc2
• InChI: 1S/C15H12FNO3/c1-20-15(19)12-4-2-3-5-13(12)17-14(18)10-6-8-11(16)9-7-10/h2-9H,1H3,(H,17,18)
• Clé InChI: KIAPWMKFHIKQOZ-UHFFFAOYSA-N

Description

Application

Exo 1 has been used as a component of the BRB80 buffer to study coat protein 1 (COPI)-mediated membrane trafficking. It has also been used as a Golgi inhibitor to study its effects on the long interspersed nuclear element-1 (L1) retrotransposition.

Actions biochimiques/physiologiques

Exo 1 is a cell-permeable methylanthranilate analog that promotes the release of adenosine diphosphate (ADP)-ribosylation factor (ARF) 1 from Golgi membranes. It also inhibits the membrane trafficking between the endoplasmic reticulum (ER) and the Golgi bodies.

Reversible inhibitor of exocytosis; Golgi ARF 1 (ADP-Ribosylation Factor) GTPase activator.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)