C3045

Cholestérol

powder, BioReagent, suitable for cell culture, ≥99%

• Synonyme(s) : 3β-hydroxy-5-cholestène, 5-Cholestén-3β-ol
• Formule empirique (notation de Hill): C₂₇H₄₆O
• Numéro CAS: 57-88-5
• Poids moléculaire : 386.65
• Numéro Beilstein : 1915888
• Numéro CE : 200-353-2
• Numéro MDL: MFCD00003646
• Code UNSPSC : 12352211
• eCl@ss : 39023139
• ID de substance PubChem : 24892329
• Nomenclature NACRES : NA.75

Propriétés

• Source biologique: ovine wool
• Gamme de produits: BioReagent
• Pureté: ≥99%
• Forme: powder
• Technique(s): cell culture | mammalian: suitable
• Point d'ébullition: 360 °C (lit.)
• Pf: 147-149 °C (lit.)
• Solubilité: H₂O: 0.002 mg/mL; Tween: soluble; ethanol: soluble; serum: soluble
• Densité: 1.067 g/mL at 25 °C (lit.)
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
• InChI: 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
• Clé InChI: HVYWMOMLDIMFJA-DPAQBDIFSA-N
• Informations sur le gène: human ... POLA1(5422) , TOP2A(7153) ; rat ... Ar(24208) , Polb(29240)

Description

Description générale

Cholesterol, a major sterol is the precursor for steroid hormones, bile acid and vitamin in mammals and coordinates endocytosis. It complexes with protein to form lipoproteins for transport in blood. It exists either as high-density lipoprotein (HDL) or low-density lipoprotein (LDL). HDL also called good cholesterol has less lipid content. LDL or bad cholesterol has high lipid content. Statin inhibition of HMG-CoA reductase enzyme in the cholesterol biosynthesis pathway controls elevated cholesterol levels in atherosclerosis and hypercholesterolemia. Low levels of cholesterol results in hypothyroidism, familial hypobetalipoproteinemia and liver disease. Imbalance of cholesterol homeostasis and intracellular cholesterol levels play a key role in cancer development. High cholesterol levels favor breast cancer progression.

Application

Cholesterol has been used:

• as a medium supplement in chorionic villous tissue culture form placenta
• as a component of hormone pellet for implantation in mice ovary
• for inducing expression of immunity-related GTPase M (IRGM) in human monocytic cell line, THP-1

Actions biochimiques/physiologiques

Constituant majeur de toutes les membranes biologiques ; le cholestérol représente ~25 % des lipides totaux du cerveau.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)