C221

Carboxy-PTIO potassium salt

• Synonyme(s) : 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt, 2-(4-Carboxyphenyl)-4,5-dihydro-4,4,5,5-tetramethyl-1H-imidazol-1-yloxy-3-oxide potassium salt
• Formule empirique (notation de Hill): C₁₄H₁₆KN₂O₄
• Numéro CAS: 148819-94-7
• Poids moléculaire : 315.39
• Numéro MDL: MFCD00216153
• Code UNSPSC : 12352200
• ID de substance PubChem : 24892474
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 100
• Essai: ≥98% (TLC)
• Forme: powder
• Pf: >270 °C
• Solubilité: H₂O: 100 mg/mL; DMSO: soluble (lit.)(lit.); methanol: soluble (lit.)(lit.)
• Température de stockage: 2-8°C
• Chaîne SMILES: [K+].CC1(C)N([O])C(c2ccc(cc2)C([O-])=O)=[N+]([O-])C1(C)C
• InChI: 1S/C14H17N2O4.K/c1-13(2)14(3,4)16(20)11(15(13)19)9-5-7-10(8-6-9)12(17)18;/h5-8H,1-4H3,(H,17,18);/q;+1/p-1
• Clé InChI: VYEUQMVIGXFZQU-UHFFFAOYSA-M

Description

Description générale

2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO) is mainly considered as a scavenger of nitric oxide (NO).

Application

Carboxy-PTIO potassium salt has been used to check the generation of hydroxyl radicals or nitric in reaction mixtures to examine the generation of nitric oxide in reaction mixture. It has also been added to neurons to analyse its effect on glucose/oxygen/serum deprivation (GOSD) condition(4)

Actions biochimiques/physiologiques

Carboxy-PTIO can make a quick reaction with nitric oxide (NO) to produce nitrogen dioxide (NO₂). It can be used to prevent hypotension and endotoxic shock, stimulated by lipopolysaccharide in- vivo. Carboxy-PTIO can also block in vitro vascular relaxation, stimulated by NO.

Reacts with nitric oxide to form carboxy-PTI derivatives which in turn inhibits nitric oxide synthase.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)