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Key Documents

Autres documents

70485

Sigma-Aldrich

Naphthol AS-E phosphate

suitable for histology

Synonyme(s) :

KG-501

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About This Item

Formule empirique (notation de Hill):
C17H13ClNO5P
Numéro CAS:
18228-17-6
Poids moléculaire :
377.72
Numéro Beilstein :
6664478
Numéro CE :
242-106-1
Numéro MDL:
MFCD00042718
Code UNSPSC :
12352204
ID de substance PubChem :
329762485
Nomenclature NACRES :
NA.83

Pureté

≥80% (HPLC)

Forme

powder

Application(s)

histology

Température de stockage

2-8°C

Chaîne SMILES 

OP(O)(=O)Oc1cc2ccccc2cc1C(=O)Nc3ccc(Cl)cc3

InChI

1S/C17H13ClNO5P/c18-13-5-7-14(8-6-13)19-17(20)15-9-11-3-1-2-4-12(11)10-16(15)24-25(21,22)23/h1-10H,(H,19,20)(H2,21,22,23)

Clé InChI

RQAQWBFHPMSXKR-UHFFFAOYSA-N

Catégories apparentées

Application

Naphthol AS-E phosphate has been used as a cAMP-response element-binding protein (CREB) inhibitor to dissolve in dimethyl sulfoxide (DMSO) as a stock solution in the study to test the hypothesis that oncostatin M (OSM) may confer neuronal resistance against 3-nitropropionic acid (3-NP).

Actions biochimiques/physiologiques

Naphthol AS-E phosphate/KG501, a small-molecule antagonist has the ability to prevent cAMP-response element-binding protein (CREB) pathway. It can also interfere with the interaction of Myb-KIX in vitro and block the actions of Myb in vivo.

Autres remarques

Histochemical substrate for alkaline phosphatases,KG-501 blocks cAMP-induction of CREB (cAMP Response Element Binding Protein)-dependent target gene transcription (Ki 10 microM)) through interference in the binding between the KID domain of CREB and KIX domain of CBP (CREB Binding Protein), classic activator-coactivator interaction.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Naphthol AS-E phosphate inhibits the activity of the transcription factor Myb by blocking the interaction with the KIX domain of the coactivator p300
Uttarkar S, et al.
Molecular Cancer Therapeutics, molcanther-molcan0662 (2015)
Phosphates of the naphthol AS series in the quantitative determination of alkaline and acid phosphatase activities in situ studied in polyacrylamide membrane model systems and by cytospectrophotometry
Lojda, Z., et al.
Histochemistry and Cell Biology, 11, 13-32 (1967)
Hui-Chi Lai et al.
PloS one, 6(11), e28280-e28280 (2011-12-06)
5-Hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5-OH-HxMF), a hydroxylated polymethoxyflavone, is found exclusively in the Citrus genus, particularly in the peels of sweet orange. In this research, we report the first investigation of the neurotrophic effects and mechanism of 5-OH-HxMF in PC12 pheochromocytoma cells. We
Nurbek Mambetsariev et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(4), 1032-1037 (2016-01-13)
The adaptor protein TNF receptor-associated factor 3 (TRAF3) regulates signaling through B-lymphocyte receptors, including CD40, BAFF receptor, and Toll-like receptors, and also plays a critical role inhibiting B-cell homoeostatic survival. Consistent with these findings, loss-of-function human TRAF3 mutations are common
Cody McGrath et al.
Frontiers in endocrinology, 12, 782194-782194 (2022-02-12)
Exercise, typically beneficial for skeletal health, has not yet been studied in lipodystrophy, a condition characterized by paucity of white adipose tissue, with eventual diabetes, and steatosis. We applied a mouse model of global deficiency of Bscl2 (SEIPIN), required for
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