C9012

Bis(cyclohexanone)oxaldihydrazone

≥95% purity (TLC), powder

• Synonyme(s) : Cuprizon, Cuprizone, Oxalic acid bis(cyclohexylidenehydrazide)
• Formule empirique (notation de Hill): C₁₄H₂₂N₄O₂
• Numéro CAS: 370-81-0
• Poids moléculaire : 278.35
• Numéro Beilstein : 2388004
• Numéro CE : 206-729-2
• Numéro MDL: MFCD00001659
• Code UNSPSC : 12171500
• ID de substance PubChem : 24893128
• Nomenclature NACRES : NA.47

Propriétés

• product name: Bis(cyclohexanone)oxaldihydrazone, ≥95% (TLC)
• Pureté: ≥95% (TLC)
• Forme: powder
• Couleur: white/clear to off-white
• Pf: 210-214 °C (lit.)
• Solubilité: acetic acid: 50 mg/mL, colorless to very faintly brown
• Application(s): diagnostic assay manufacturing; hematology; histology
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C(N\N=C1\CCCCC1)C(=O)N\N=C2/CCCCC2
• InChI: 1S/C14H22N4O2/c19-13(17-15-11-7-3-1-4-8-11)14(20)18-16-12-9-5-2-6-10-12/h1-10H2,(H,17,19)(H,18,20)
• Clé InChI: DSRJIHMZAQEUJV-UHFFFAOYSA-N

Description

Application

• Bis(cyclohexanone)oxaldihydrazone (Cuprizone) has been used in mice to study the effect of NG2 (neural/glial antigen 2) proteoglycan on toxic-induced demyelination.
• It has been used to induce demyelination in mice.
• It has been used to study cuprizone-induced demyelination and remyelination in the corpus callosum of mice.

Actions biochimiques/physiologiques

Bis(cyclohexanone)oxaldihydrazone (Cuprizone) is a copper chelator. It results in oligodendroglial cell death, thereby leading to demyelination, astrogliosis and microglia activation. Cuprizone is widely used to study mitochondrial dysfunction-associated primary demyelination and remyelination in the corpus callosum.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)