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Flunixin

VETRANAL®, analytical standard

Synonyme(s) :

2-[2-Methyl-3-(trifluoromethyl)phenylamino]nicotinic acid

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About This Item

Formule empirique (notation de Hill):
C14H11F3N2O2
Numéro CAS:
Poids moléculaire :
296.24
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24

Qualité

analytical standard

Niveau de qualité

Gamme de produits

VETRANAL®

Durée de conservation

limited shelf life, expiry date on the label

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Application(s)

forensics and toxicology
pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

Cc1c(Nc2ncccc2C(O)=O)cccc1C(F)(F)F

InChI

1S/C14H11F3N2O2/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12/h2-7H,1H3,(H,18,19)(H,20,21)

Clé InChI

NOOCSNJCXJYGPE-UHFFFAOYSA-N

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Description générale

Flunixin is a potent nonsteroidal anti-inflammatory drug, primarily used as an anti-inflammatory agent and analgesic for the short-term treatment of moderate pain and inflammation in farm animals. It is also effective in inhibiting the synthesis of prostaglandins.
Flunixin is classified under the group of non-steroidal anti-inflammatory drugs (NSAIDs).

Application

Flunixin may be used as a reference standard for the determination of NSAID drug, flunixin in biological samples using high-performance liquid chromatography with diode array detection (HPLC-DAD)/particle beam mass spectrometry (PB-MS)/atmospheric pressure ionization mass spectrometry (API-MS) and gas chromatography coupled to mass spectrometry (GC-MS).
Flunixin may be used as an analytical reference standard for the determination of flunixin in:
  • Bovine muscle samples by hydrophilic interaction liquid chromatography-electrospray-tandem mass spectrometry (HILIC-ESI-MS/MS) equipped with selected reaction monitoring (SRM) detection.
  • Animal tissues by dispersive-solid phase extraction (d-SPE) and enhanced matrix removal for lipids (EMR-L), followed by analysis using ultra-high performance liquid chromatography-triple quadrupole or quadrupole-time-of-flight (UHPLC-QqQ or UHPLC-Q/TOF) methods in conjunction with ESI-MS/MS operating on multiple reaction monitoring (MRM) mode of detection as well as ESI-LC-MS/MS with SRM detection mode.
  • Porcine muscle samples by ESI-LC-MS/MS with MRM detection mode.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Produits recommandés

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Informations légales

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogrammes

Skull and crossbones

Mention d'avertissement

Danger

Mentions de danger

Classification des risques

Acute Tox. 3 Oral

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Certificats d'analyse (COA)

Lot/Batch Number

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Les clients ont également consulté

Online eluent-switching technique coupled anion-exchange liquid chromatography-ion trap tandem mass spectrometry for analysis of non-steroidal anti-inflammatory drugs in pig serum.
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Journal of Chromatography A, 1422, 222-229 (2015)
C Beretta et al.
Pharmacological research, 52(4), 302-306 (2005-06-09)
We report on the inhibitory activity of the NSAIDs meloxicam, carprofen, phenylbutazone and flunixin, on blood cyclooxygenases in the horse using in vitro enzyme-linked assays. As expected, comparison of IC50 indicated that meloxicam and carprofen are more selective inhibitors of
Eva Weiss et al.
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Simultaneous analysis of flunixin, naproxen, ethacrynic acid, indomethacin, phenylbutazone, mefenamic acid and thiosalicycic acid in plasma and urine by high-performance liquid chromatography and gas chromatography?mass spectrometry.
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